| CAS: | 43077-30-1 | |||
| 分子式: | C22H29OP | |||
| 分子量: | 340.447 | |||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||
| D970213 | MACKLIN | DPO-1,KV1.5和IKurcurrent的通道阻滞剂 | 98% | 1018元/5mg; | 展开 | ||||||||||||||||||||||||||||||
储存：-20°C, 避光 | |||||||||||||||||||||||||||||||||||
| D7443 | Sigma-Aldrich | DPO-1 | needles, >97% (NMR) | 1700.13元/5 mg; 10316.7元/25 MG; | 展开 | ||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 DPO-1 is an inhibitor of human Kv1.5 potassium channel; representative blocker of a novel pharmacophore. The Kv1.5 potassium channel, which underlies the ultrarapid delayed rectifier current, IKur, is reported to be enriched in human atrium versus ventricle, and has been proposed as a target for novel atrial antiarrhythmic therapy. The administration of the IKur blocker (2-isopropyl-5-methyl-cyclohexyl) diphenylphosphine oxide (DPO-1) increases myocardial refractoriness in both atrium and ventricle of rat, but produces an atrial-selective increase in refractoriness in primates; appears to be 15-fold more selective for Kv1.5 vs Kv3.1 channels expressed in Xenopus oocytes. IC50 = 0.16-0.76 μM at 0.1 Hz pulsing frequency; Kd = 0.6 μM. 特点和优势 This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. 基本信息
产品性质
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