| CAS: | 251945-92-3 | ||||||
| 分子式: | C18H20N4O | ||||||
| 分子量: | 308.38 | ||||||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||
| H887669 | MACKLIN | 4-((2-苯基-7H-吡咯并[2,3-d]嘧啶-4-基)氨基)环己醇 | 98% | 818元/100mg; 1650元/250mg; | 展开 | ||||||||||||||||||||||||||||||
储存：2-8℃，干燥，密封， 状态：淡黄色固体 | |||||||||||||||||||||||||||||||||||
| H792912 | MACKLIN | 4-((2-苯基-7H-吡咯并[2, 3-d]嘧啶-4-基)氨基)环己醇 | 10mM in DMSO | 648元/1ml; | 展开 | ||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||
| SML1931 | Sigma-Aldrich | SLV320 | ≥98% (HPLC) | 1318.46元/5 MG; | 展开 | ||||||||||||||||||||||||||||||
产品说明 生化/生理作用 SLV320 is an orally active, high-affinity adenosine receptor A1 antagonist (pKi = 9.0 against 3H-DPCPX for binding human A1R and 8.6 against 3H-CCPA for binding rat A1R) that exhibits higher A1R-selectivity than DPCPX over other adenosine receptor subtypes (Fold-selectivity/subtypes = 200/hA3, 398/hA2a, 3981/hA2b). SLV320 displays much reduced or little affinity toward a panel of 94 other receptors and no inhibitory activity against PDE1-6 (IC50 ≥1 μM). SLV320 selectively reduces A1R-mediated bradycardia (ED50 = 0.49 mg/kg via p.o. or 0.25 mg/kg via i.v. 10 min prior to 100 μg/kg adenosine i.v. challenge), but not A2R-dependent hypotension (up to 2 mg/kg) among adenosin-challenged rats. When administered via food intake, SLV320 efficacy is demonstrated in experimental models of chronic renal failure (CRF; 10 mg/kg/day) and liver cirrhosis (5.1 mg/kg/day p.o.) in rats in vivo. 基本信息
产品性质
安全信息
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