CAS 247580-43-4; sb 328437

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CAS:

247580-43-4

分子式:

C₂₁H₁₈N₂O₅

分子量:

378.38

英文名称:

sb 328437

l-phenylalanine, n-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester

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货号

品牌

产品名称

规格

包装、参考价格

详情

S969943

MACKLIN

SB 328437,CCR3拮抗剂

98%

698元/5mg; 1384元/10mg; 10850元/100mg;

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储存：-20°C, 干燥

SML0207

Sigma-Aldrich

SB 328437

≥98% (HPLC)

1528.02元/5 MG;

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产品说明

应用

SB 328437 may be used to study CCR3-mediated cell signaling in asthma models.

包装

5, 25 mg in glass bottle

生化/生理作用

SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.
SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.

特点和优势

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₁H₁₈N₂O₅
分子量	378.38
MDL编号	MFCD16618397
PubChem化学物质编号	329825229
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to tan
溶解性	DMSO: ≥10 mg/mL
创始人	GlaxoSmithKline
储存温度	2-8℃
SMILES string	COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23
InChI	1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChI key	VMFGCGRAIBLAFY-IBGZPJMESA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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