| CAS: | 2143475-98-1 | ||
| 分子式: | C20H16N2O | ||
| 分子量: | 300.35 | ||
| 英文名称: |
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| 用途: | GeA-69 是一种选择性的，高细胞渗透性的 PARP14 变构抑制剂，靶向作用于其 macrodomain 2 (MD2)，Kd 值为 2.1 µM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||
| G880443 | MACKLIN | GeA-69 | ≥99% | 214元/5mg; 280元/10mg; 730元/50mg; | 展开 | ||||||||||||||||||||||||||||
储存：2-8℃ 状态：灰白色到棕色粉末 | |||||||||||||||||||||||||||||||||
| G797651 | MACKLIN | GeA-69 | 10mM in DMSO | 648元/1ml; | 展开 | ||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||
| SML2267 | Sigma-Aldrich | GeA-69 | ≥98% (HPLC) | 798.09元/5 MG; 3224.81元/25 MG; | 展开 | ||||||||||||||||||||||||||||
产品说明 生化/生理作用 GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites. 基本信息
产品性质
安全信息
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