CAS 2143467-62-1; bpk-29

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CAS:

2143467-62-1

英文名称:

bpk-29

2-chloro-n-[hexahydro-1-[4-(4-morpholinyl)benzoyl]-1h-azepin-4-yl]-n-(phenylmethyl)-acetamide

n-benzyl-2-chloro-n-[1-(4-morpholin-4-yl-benzoyl)-azepan-4-yl]-acetamide

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货号

品牌

产品名称

规格

包装、参考价格

详情

SML2305

Sigma-Aldrich

BPK-29

≥98% (HPLC)

944.89元/5 MG; 3816.61元/25 MG;

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产品说明

生化/生理作用

BPK-29 is a small molecule inhibitor that blocks the nuclear factor erythroid 2–related factor 2 (NRF2) pathway. It targets the cysteine 274 residue in the nuclear receptor subfamily 0 group B member 1 (NR0B1) and disrupts protein-protein interactions in non-small-cell lung cancer (NSCLC) cell proteomes.
BPK-29 is a potent and selective NR0B1 ligand that covalently binds to NR0B1 Cys 274. BPK-29 inhibits the NR0B1-SNW1 interaction. It inhibits the anchorage-independent growth of KEAP1-mutant cancer cells.

基本信息

经验(实验)分子式	C₂₆H₃₂ClN₃O₃
分子量	470.00
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(CCl)N(C1CCN(C(C2=CC=C(N3CCOCC3)C=C2)=O)CCC1)CC4=CC=CC=C4

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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