CAS 2049868-46-2; gsk′963; gsk-963

CAS:

2049868-46-2

分子式:

C₁₄H₁₈N₂O

分子量:

230.31

中文名称:

gsk′963

gsk′963a

gsk′ 963a

英文名称:

gsk-963

gsk 963

gsk963

gsk963a

1-[(5S)-4,5-dihydro-5-phenyl-1h-pyrazol-1-yl]-2,2-dimethyl-1-propanone; 2,2-dimethyl-1-(5(S)-phenyl-4,5-dihydro-pyrazol-1-yl)-propan-1-one

gsk-963a

用途:

GSK'963是RIP1 kinase的手性小分子抑制剂，在FP结合实验中IC50值为29 nM。它对RIP1的选择性是对其他339种激酶的10,000倍以上。

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货号

品牌

产品名称

规格

包装、参考价格

详情

G795034

MACKLIN

GSK'963

10mM in DMSO

598元/1ml;

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储存：-20°C

G873074

MACKLIN

GSK'963

99%

809元/5mg; 2490元/25mg; 2988元/100mg;

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储存：-20℃
状态：粉末

SML2376

Sigma-Aldrich

GSK′963

≥98% (HPLC)

1023.54元/5 MG; 4128.87元/25 MG;

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产品说明

生化/生理作用

GSK′963 (GSK′963A) is a brain-penetrant, highly potent and selective ATP site-targeting receptor-interacting protein 1 kinase (RIP1; RIPK1) inhibitor (IC50 = 0.8-8 nM with 50 μM ATP; IC50 >10 μM against RIPK2/3/5 and 335 other kinases) that protects against TNFα/zVAD-induced necroptosis (EC50 = 1/4 nM in mouse L929/human U937 cultures) and blocks Y. pestis-induced death of murine fetal liver macrophages (1 μM). GSK′963 prevents lethal hypothermia by acute sterile shock (2 mg/kg i.p. 15 min prior to TNFα/zVAD i.v.) and protects against acute neuronal death upon autologous blood intracerebral hemorrhage induction in mice in vivo (25 mg/kg/3 hr i.p.).

基本信息

经验(实验)分子式	C₁₄H₁₈N₂O
分子量	230.31

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(C(C)(C)C)N1[C@H](C2=CC=CC=C2)CC=N1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable