CAS 204697-65-4; n-[2-[5-氨基-1(S)-[4-(4-吡啶基)哌嗪-1-甲酰基]戊基氨基]-1(R)-(3,5-二溴-4-羟基苄基)-2-氧代乙基]-4-(2-氧代-1,2,3,4-四氢喹唑啉-3-基)哌啶-1-甲酰胺; olcegepant

CAS:

204697-65-4

分子式:

C₃₈H₄₇Br₂N₉O₅

分子量:

869.65

中文名称:

n-[2-[5-氨基-1(S)-[4-(4-吡啶基)哌嗪-1-甲酰基]戊基氨基]-1(R)-(3,5-二溴-4-羟基苄基)-2-氧代乙基]-4-(2-氧代-1,2,3,4-四氢喹唑啉-3-基)哌啶-1-甲酰胺

英文名称:

olcegepant

bibn-4096

bibn-4096bs

bibn4096bs

bibn 4096bs

n-[2-[5-amino-1(S)-[4-(4-pyridinyl)piperazin-1-ylcarbonyl]pentylamino]-1(R)-(3,5-dibromo-4-hydroxybenzyl)-2-oxoethyl]-4-(2-oxo-1,2,3,4-tetrahydroquinazolin-3-yl)piperidine-1-carboxamide

用途:

Olcegepant是有效和选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50 和 Ki 分别为0.03 nM，14.4 pM。

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货号

品牌

产品名称

规格

包装、参考价格

详情

O880666

MACKLIN

Olcegepant

≥99%

878元/2mg; 1884元/5mg;

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储存：2-8℃

SML2426

Sigma-Aldrich

BIBN4096BS

≥95% (HPLC)

1023.54元/5 MG; 4128.87元/25 MG;

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产品说明

生化/生理作用

BIBN4096BS (Olcegepant) is a potent calcitonin gene-related peptide (CGRP) receptor antagonist with higher affinity/potency toward human over rat & mouse receptor (human/rat Ki = 14.4 pM/3.4 nM by binding assay; human/mouse Kb = 8 pM//7.711 nM by cellular cAMP assay). BIBN4096BS inhibits facial blood flow by electrical stimulation of marmoset monkey trigeminal ganglion (IC50 = 3 μg/kg i.v.) without any intrinsic cardiovascular effects. Studies using anaesthetized rats reveals that BIBN4096BS antagonism against trigeminal nociceptive stimulation by capsaicin is limited to the spinal trigeminal nucleus, but not trigeminal ganglion. Also widely employed for in vivo studies in mice.

基本信息

经验(实验)分子式	C₃₈H₄₇Br₂N₉O₅
分子量	869.65
MDL编号	MFCD07772306

产品性质

测定	≥95% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
InChI	1S/C38H47Br2N9O5/c39-29-21-25(22-30(40)34(29)50)23-33(45-37(53)48-15-10-28(11-16-48)49-24-26-5-1-2-6-31(26)44-38(49)54)35(51)43-32(7-3-4-12-41)36(52)47-19-17-46(18-20-47)27-8-13-42-14-9-27/h1-2,5-6,8-9,13-14,21-22,28,32-33,50H,3-4,7,10-12,15-20,23-24,41H2,(H,43,51)(H,44,54)(H,45,53)
InChI key	ITIXDWVDFFXNEG-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable