CAS 124753-97-5; N-HEXANOYL-D-ERYTHRO-SPHINGOSINE

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N864465

MACKLIN

N-hexanoyl-D-erythro-sphingosine

>99%

865元/5mg; 3289元/25mg;

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储存：-20°C
状态：白色到灰白色固体

451703

J&K

N-Hexanoyl-D-sphingosine

98%

200元/1MG; 798元/5MG;

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基本信息

分子式	C₂₄H₄₇NO₃
分子量	397.63
熔点	76-77
MDL编码	MFCD00870174
存储条件	Freezer -20℃

生化/生理作用

Cell-permeable analog of ceramide; stimulates protein phosphatase 2A; activates MAP kinase; induces apoptosis in human leukemia HL-60 cells

安全信息

WGK	3
TSCA	否

H6524

Sigma-Aldrich

N-Hexanoyl-D-sphingosine

≥98% (TLC), synthetic

1520.74元/5 MG;

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产品说明

包装

1, 5 mg in glass bottle

生化/生理作用

Cell-permeable analog of ceramide; stimulates protein phosphatase 2A; activates MAP kinase; induces apoptosis in human leukemia HL-60 cells

基本信息

经验(实验)分子式	C₂₄H₄₇NO₃
分子量	397.63
MDL编号	MFCD00870174
PubChem化学物质编号	24895750
NACRES	NA.77

产品性质

质量水平	200
生物来源	synthetic
测定	≥98% (TLC)
储存温度	−20℃
SMILES string	OC[C@]([H])(NC(CCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI	1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+/t22-,23+/m0/s1
InChI key	NPRJSFWNFTXXQC-QFWQFVLDSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

376650

Sigma-Aldrich

D-erythro-Sphingosine, N-Hexanoyl--CAS 124753-97-5-Calbiochem

Biologically active, cell-permeable, non-physiological ceramide analog.

1444.23元/5 MG;

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产品说明

一般描述

Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G₀/G₁ phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
Biologically active, cell-permeable, nonphysiological ceramide analog. Stimulates cytosolic serine/threonine protein phosphatase in T9 cells and induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. Induces a dramatic arrest in the G_o/G₁ phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis in Molt-4 leukemia cells.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Effective concentration: 10 nM in activating protein phosphatase 2A (PP2A)
Primary Target
MAP kinase, protein phosphatase 2A (PP2A)

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他说明

Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
Raines, M.A., et al. 1993. J. Biol. Chem.268, 14572.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem.267, 5048.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₄H₄₇NO₃
分子量	397.63
MDL编号	MFCD00870174

产品性质

质量水平	100
测定	≥98% (TLC)
形式	waxy solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	ethanol: 25 mg/mL DMSO: soluble
运输	ambient
储存温度	−20℃
InChI	1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+
InChI key	NPRJSFWNFTXXQC-VHEBQXMUSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

860506P

Avanti

C6 Ceramide (d18:1/6:0)

Avanti Polar Lipids 860506P, powder

1033.4元/5 MG; 1780.43元/10 MG;

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产品说明

一般描述

C6神经酰胺(d18:1/6:0)是一种具有细胞通透性的短链神经酰胺。它包含通过酰胺键与脂肪酰基链相连的氨基醇链。

应用

C6神经酰胺(d18:1/6:0)已被作为化疗药物用于测试其在乳腺癌细胞和卵巢癌细胞系中的抗肿瘤作用。它还被用于测试癌细胞中的化疗增敏作用。

生化/生理作用

C6神经酰胺(d18:1/6:0)可参与到增殖抑制和细胞凋亡诱导。当与酸性神经酰胺酶抑制剂DM102，即[(2R,3Z)-N-(1-羟基十八烷基-3-en-2-基)新戊酰酰胺]结合使用时，可有助于人乳腺癌细胞系的细胞死亡。C6神经酰胺可作为化疗的一种辅助手段。它可通过AKT(丝氨酸/苏氨酸特异性蛋白激酶)去磷酸化和α-微管蛋白乙酰化引发抗肿瘤作用。

包装

5 mL琥珀色玻璃螺旋盖小瓶(860506P-10mg)
5 mL琥珀色玻璃螺旋盖小瓶(860506P-5mg)

基本信息

经验(实验)分子式	C₂₄H₄₇NO₃
分子量	397.63
NACRES	NA.25

产品性质

形式	powder
包装	pkg of 1 × 10 mg (860506P-10mg) pkg of 1 × 5 mg (860506P-5mg)
manufacturer/tradename	Avanti Polar Lipids 860506P
运输	dry ice
储存温度	−20℃
SMILES string	OC[C@]([H])(NC(CCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI	1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+
InChI key	NPRJSFWNFTXXQC-VHEBQXMUSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable